Autosomal suppression and fitness costs of an old driving X chromosome in Drosophila testacea

Simple item page
dc.contributor.authorKeais, Graeme
dc.contributor.authorLu, Sijia
dc.contributor.authorPerlman, Steve
dc.date.accessioned2020-05-19T19:18:32Z
dc.date.copyright2020en_US
dc.date.issued2020
dc.description.abstractDriving X chromosomes (XDs) bias their own transmission through males by killing Y‐bearing gametes. These chromosomes can in theory spread rapidly in populations and cause extinction, but many are found as balanced polymorphisms or as “cryptic” XDs shut down by drive suppressors. The relative likelihood of these outcomes and the evolutionary pathways through which they come about are not well understood. An XD was recently discovered in the mycophagous fly, Drosophila testacea, presenting the opportunity to compare this XD with the well‐studied XD of its sister species, Drosophila neotestacea. Comparing features of independently evolved XDs in young sister species is a promising avenue towards understanding how XDs and their counteracting forces change over time. In contrast to the XD of D. neotestacea, we find that the XD of D. testacea is old, with its origin predating the radiation of three species: D. testacea, D. neotestacea and their shared sister species, Drosophila orientacea. Motivated by the suggestion that older XDs should be more deleterious to carriers, we assessed the effect of the XD on both male and female fertility. Unlike what is known from D. neotestacea, we found a strong fitness cost in females homozygous for the XD in D. testacea: a large proportion of homozygous females failed to produce offspring after being housed with males for several days. Our male fertility experiments show that although XD male fertility is lower under sperm‐depleting conditions, XD males have comparable fertility to males carrying a standard X chromosome under a free‐mating regime, which may better approximate conditions in wild populations of D. testacea. Lastly, we demonstrate the presence of autosomal suppression of X chromosome drive. Our results provide support for a model of XD evolution where the dynamics of young XDs are governed by fitness consequences in males, whereas in older XD systems, both suppression and fitness consequences in females likely supersede male fitness costs.en_US
dc.description.embargo2021-01-28
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by an NSERC Discovery Grant to SP and an NSERC CGS-M to GK.en_US
dc.identifier.citationKeais, G. Lu, S., P., & Perlman, S. J. (2020). Autosomal suppression and fitness costs of an old driving X chromosome in Drosophila testacea. Journal of Evolutionary Biology, 33(5), 619-628. https://doi.org/10.1111/jeb.13596.en_US
dc.identifier.urihttps://doi.org/10.1111/jeb.13596
dc.identifier.urihttp://hdl.handle.net/1828/11752
dc.language.isoenen_US
dc.publisherJournal of Evolutionary Biologyen_US
dc.subjectdrosophila
dc.subjectgamete-killing
dc.subjectgene drive
dc.subjectgenetic conflict
dc.subjectgenomic conflict
dc.subjectmeiotic drive
dc.subjectsegregation distortion
dc.subjectselfish genetic elements
dc.subjectsex ratio
dc.subjectX chromosome
dc.subject.departmentDepartment of Biology
dc.titleAutosomal suppression and fitness costs of an old driving X chromosome in Drosophila testaceaen_US
dc.typePostprinten_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Keais_Graeme_JEvolBiol_2020.pdf
Size:
2.15 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.