Contrasting Olfaction, Vision, and Audition as Predictors of Cognitive Change and Impairment in Non-Demented Older Adults

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dc.contributor.authorKeller, C.J.C.
dc.contributor.authorBrewster, P.W.H.
dc.contributor.authorDixon, R.A.
dc.contributor.authorMacDonald, Stuart W.S.
dc.date.accessioned2021-10-01T20:48:28Z
dc.date.available2021-10-01T20:48:28Z
dc.date.copyright2018en_US
dc.date.issued2018
dc.description.abstractObjective: This study examines the relative utility of a particular class of non-invasive functional biomarkers -- sensory functions -- for detecting those at risk of cognitive decline and impairment. Three central research objectives were examined including whether: (1) olfactory function, vision, and audition exhibited significant longitudinal declines in non-demented older adults, (2) multi-wave change for these sensory function indicators predicted risk of mild cognitive impairment, and (3) change within persons for each sensory measure shared dynamic time-varying associations with within-person change in cognitive functioning. Method: A longitudinal sample (n=408) from the Victoria Longitudinal Study was assembled. Three cognitive status subgroups were identified: not impaired cognitively (NIC), single assessment mild cognitive impairment (SA-MCI), and multiple assessment mild cognitive impairment (MAMCI). Results: We tested independent predictive associations, contrasting change in sensory function as predictors of cognitive decline and impairment, utilizing both linear mixed models and logistic regression analysis. Olfaction and, to a lesser extent, vision were identified as the most robust predictors of cognitive status and decline; audition showed little predictive influence. Conclusions: These findings underscore the potential utility of deficits in olfactory function, in particular, as an early marker of age- and pathology-related cognitive decline. Functional biomarkers may represent potential candidates for use in the early stages of a multistep screening approach for detecting those at risk of cognitive impairment, as well as for targeted intervention.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was supported by a grant from the National Institutes of Health (National Institute on Aging) to Roger A. Dixon (R01 AG008235). Dr. Dixon was also supported by the Canada Research Chairs program. Stuart W.S. MacDonald was supported by a grant from the Natural Sciences and Engineering Research Council of Canada, as well as by the Royal Society of Canada College of New Scholars, Artists and Scientists.en_US
dc.identifier.citationMacDonald, S.W.S., Keller, C.J.C., Brewster, P.W.H., & Dixon, R.A. (2018). Contrasting Olfaction, Vision, and Audition as Predictors of Cognitive Change and Impairment in Non-Demented Older Adults. Neuropsychology, 32(4), 450-460. https://dx.doi.org/10.1037/neu0000439en_US
dc.identifier.urihttps://dx.doi.org/10.1037/neu0000439
dc.identifier.urihttp://hdl.handle.net/1828/13423
dc.language.isoenen_US
dc.publisherNeuropsychologyen_US
dc.subjectsensory function
dc.subjectolfaction
dc.subjectfunctional biomarkers
dc.subjectcognitive change
dc.subjectcognitive aging
dc.subjectVictoria Longitudinal Study
dc.subjectmild cognitive impairment
dc.subjectInstitute on Aging and Lifelong Health
dc.subject.departmentDepartment of Psychology
dc.titleContrasting Olfaction, Vision, and Audition as Predictors of Cognitive Change and Impairment in Non-Demented Older Adultsen_US
dc.typeArticleen_US

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