A Chan–Evans–Lam approach to trisubstituted vinyl ethers
Date
2021
Authors
Sader, Jonathan K.
Molder, Bryce A.
Wulff, Jeremy E.
Journal Title
Journal ISSN
Volume Title
Publisher
Organic & Biomolecular Chemistry
Abstract
Trisubstituted vinyl ethers were accessed via Chan–Evans–Lam coupling of vinyl trifluoroborates and primary aliphatic alcohols. This approach complements prior methods that required the use of neat liquid alcohol coupling partners. A palladium-catalyzed redox-relay Heck reaction was used to convert several vinyl ethers into aldehyde-functionalized 1,3-dihydroisobenzofurans.
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Citation
J. K. Sader, B. A. Molder and J. E. Wulff (2021) A Chan–Evans–Lam Approach to Trisubstituted Vinyl Ethers. Organic & Biomolecular Chemistry, 19, 9649–6018. https://doi.org/10.1039/D1OB01827B