A Chan–Evans–Lam approach to trisubstituted vinyl ethers
| dc.contributor.author | Sader, Jonathan K. | |
| dc.contributor.author | Molder, Bryce A. | |
| dc.contributor.author | Wulff, Jeremy E. | |
| dc.date.accessioned | 2026-02-05T21:52:31Z | |
| dc.date.available | 2026-02-05T21:52:31Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Trisubstituted vinyl ethers were accessed via Chan–Evans–Lam coupling of vinyl trifluoroborates and primary aliphatic alcohols. This approach complements prior methods that required the use of neat liquid alcohol coupling partners. A palladium-catalyzed redox-relay Heck reaction was used to convert several vinyl ethers into aldehyde-functionalized 1,3-dihydroisobenzofurans. | |
| dc.description.reviewstatus | Reviewed | |
| dc.description.scholarlevel | Faculty | |
| dc.description.sponsorship | J.S. is grateful to the Natural Sciences and Engineering Research Council of Canada (NSERC) for a fellowship, and J.W. acknowledges the Canada Research Chairs program for salary support. We thank Chris Barr and Dr. Tyler Trefz for expert assistance with 2H{1H} NMR and HRMS analysis, respectively. We also thank Prof. David Leitch for helpful discussions. | |
| dc.identifier.citation | J. K. Sader, B. A. Molder and J. E. Wulff (2021) A Chan–Evans–Lam Approach to Trisubstituted Vinyl Ethers. Organic & Biomolecular Chemistry, 19, 9649–6018. https://doi.org/10.1039/D1OB01827B | |
| dc.identifier.uri | https://doi.org/10.1039/D1OB01827B | |
| dc.identifier.uri | https://hdl.handle.net/1828/23136 | |
| dc.language.iso | en | |
| dc.publisher | Organic & Biomolecular Chemistry | |
| dc.subject.department | Department of Chemistry | |
| dc.title | A Chan–Evans–Lam approach to trisubstituted vinyl ethers | |
| dc.type | Postprint |