PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection
Date
2020
Authors
Sanchez-Arias, Juan C.
Wicki-Stordeur, Leigh E.
Candlish, Rebecca C.
van der Slagt, Emma
Paci, Irina
Rao, Praveen P. N.
MacVicar, Brian A.
Swayne, Leigh Anne
Journal Title
Journal ISSN
Volume Title
Publisher
Cell Calcium
Abstract
A new study by Yang and colleagues has revealed that TNF-alpha regulates PANX1 levels through an NF-kB-dependent mechanism in human endothelial cells. PANX1 modulates Ca2+ influx contributing to IL-1beta production independent of purinergic signaling. These novel findings expand our understanding of TNF-alpha-mediated upregulation of IL-1beta with implications for responses to tissue injury and infection.
Description
Keywords
endothelial cells, intracellular calcium, pannexin 1, TNF-alpha, NF-kB, cytokines, transcription, IL-1beta, inflammation
Citation
Sanchez Arias, J. C., Wicki-Stordeur, L. E., Candlish, R. C., van der Slagt, E. Paci, I., Rao, P. P. N., MacVicar, B. A., & Swayne, L. A. (2020). PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection. Cell Calcium, 90, 1-3. https://doi.org/10.1016/j.ceca.2020.102253.