PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection

Simple item page
dc.contributor.authorSanchez-Arias, Juan C.
dc.contributor.authorWicki-Stordeur, Leigh E.
dc.contributor.authorCandlish, Rebecca C.
dc.contributor.authorvan der Slagt, Emma
dc.contributor.authorPaci, Irina
dc.contributor.authorRao, Praveen P. N.
dc.contributor.authorMacVicar, Brian A.
dc.contributor.authorSwayne, Leigh Anne
dc.date.accessioned2020-07-22T20:19:32Z
dc.date.copyright2020en_US
dc.date.issued2020
dc.description.abstractA new study by Yang and colleagues has revealed that TNF-alpha regulates PANX1 levels through an NF-kB-dependent mechanism in human endothelial cells. PANX1 modulates Ca2+ influx contributing to IL-1beta production independent of purinergic signaling. These novel findings expand our understanding of TNF-alpha-mediated upregulation of IL-1beta with implications for responses to tissue injury and infection.en_US
dc.description.embargo2021-07-13
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationSanchez Arias, J. C., Wicki-Stordeur, L. E., Candlish, R. C., van der Slagt, E. Paci, I., Rao, P. P. N., MacVicar, B. A., & Swayne, L. A. (2020). PANX1 in inflammation heats up: New mechanistic insights with implications for injury and infection. Cell Calcium, 90, 1-3. https://doi.org/10.1016/j.ceca.2020.102253.en_US
dc.identifier.urihttps://doi.org/10.1016/j.ceca.2020.102253
dc.identifier.urihttp://hdl.handle.net/1828/11954
dc.language.isoenen_US
dc.publisherCell Calciumen_US
dc.subjectendothelial cells
dc.subjectintracellular calcium
dc.subjectpannexin 1
dc.subjectTNF-alpha
dc.subjectNF-kB
dc.subjectcytokines
dc.subjecttranscription
dc.subjectIL-1beta
dc.subjectinflammation
dc.subject.departmentDepartment of Biology
dc.subject.departmentDepartment of Mathematics and Statistics
dc.titlePANX1 in inflammation heats up: New mechanistic insights with implications for injury and infectionen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
SanchezArias_JuanC_CellCalcium_2020.pdf
Size:
766.36 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.