Trace cancer biomarker quantification using polystyrene-functionalized gold nanorods
Date
2014-11
Authors
Wu, Jian
Li, Wei
Hajisalem, Ghazal
Lukach, Ariella
Kumacheva, Eugenia
Hof, Fraser
Gordon, Reuven
Journal Title
Journal ISSN
Volume Title
Publisher
Biomedical Optics Express
Abstract
We demonstrate the application of polystyrene-functionalized gold nanorods (AuNRs) as a platform for surface enhanced Raman scattering (SERS) quantification of the exogenous cancer biomarker Acetyl Amantadine (AcAm). We utilize the hydrophobicity of the polystyrene attached to the AuNR surface to capture the hydrophobic AcAm from solution, followed by drying and detection using SERS. We achieve a detection limit of 16 ng/mL using this platform. This result shows clinical potential for low-cost early cancer detection.
Description
Keywords
Surface-enhanced Raman scattering, Surface plasmons, Optical sensing and sensors
Citation
Wu, J., Li, W., Hajisalem, G., Lukach, A., Kumacheva, E., Hof, F. & Gordon, R. (2014). Trace cancer biomarker quantification using polystyrene-functionalized gold nanorods. Biomedical Optics Express, 5(12), 4101-4107.