Trace cancer biomarker quantification using polystyrene-functionalized gold nanorods

Date

2014-11

Authors

Wu, Jian
Li, Wei
Hajisalem, Ghazal
Lukach, Ariella
Kumacheva, Eugenia
Hof, Fraser
Gordon, Reuven

Journal Title

Journal ISSN

Volume Title

Publisher

Biomedical Optics Express

Abstract

We demonstrate the application of polystyrene-functionalized gold nanorods (AuNRs) as a platform for surface enhanced Raman scattering (SERS) quantification of the exogenous cancer biomarker Acetyl Amantadine (AcAm). We utilize the hydrophobicity of the polystyrene attached to the AuNR surface to capture the hydrophobic AcAm from solution, followed by drying and detection using SERS. We achieve a detection limit of 16 ng/mL using this platform. This result shows clinical potential for low-cost early cancer detection.

Description

Keywords

Surface-enhanced Raman scattering, Surface plasmons, Optical sensing and sensors

Citation

Wu, J., Li, W., Hajisalem, G., Lukach, A., Kumacheva, E., Hof, F. & Gordon, R. (2014). Trace cancer biomarker quantification using polystyrene-functionalized gold nanorods. Biomedical Optics Express, 5(12), 4101-4107.