Trace cancer biomarker quantification using polystyrene-functionalized gold nanorods

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dc.contributor.authorWu, Jian
dc.contributor.authorLi, Wei
dc.contributor.authorHajisalem, Ghazal
dc.contributor.authorLukach, Ariella
dc.contributor.authorKumacheva, Eugenia
dc.contributor.authorHof, Fraser
dc.contributor.authorGordon, Reuven
dc.date.accessioned2016-04-22T22:51:11Z
dc.date.available2016-04-22T22:51:11Z
dc.date.copyright2014en_US
dc.date.issued2014-11
dc.description.abstractWe demonstrate the application of polystyrene-functionalized gold nanorods (AuNRs) as a platform for surface enhanced Raman scattering (SERS) quantification of the exogenous cancer biomarker Acetyl Amantadine (AcAm). We utilize the hydrophobicity of the polystyrene attached to the AuNR surface to capture the hydrophobic AcAm from solution, followed by drying and detection using SERS. We achieve a detection limit of 16 ng/mL using this platform. This result shows clinical potential for low-cost early cancer detection.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work is funded by a Genome BC Proof-of-Concept grant, the NSERC Strategic Network for Bioplasmonic Systems (Biopsys) grant, and Biomark Technologies.en_US
dc.identifier.citationWu, J., Li, W., Hajisalem, G., Lukach, A., Kumacheva, E., Hof, F. & Gordon, R. (2014). Trace cancer biomarker quantification using polystyrene-functionalized gold nanorods. Biomedical Optics Express, 5(12), 4101-4107.en_US
dc.identifier.urihttp://dx.doi.org/10.1364/BOE.5.004101
dc.identifier.urihttp://hdl.handle.net/1828/7175
dc.language.isoenen_US
dc.publisherBiomedical Optics Expressen_US
dc.subjectSurface-enhanced Raman scattering
dc.subjectSurface plasmons
dc.subjectOptical sensing and sensors
dc.subject.departmentDepartment of Electrical and Computer Engineering
dc.subject.departmentDepartment of Chemistry
dc.titleTrace cancer biomarker quantification using polystyrene-functionalized gold nanorodsen_US
dc.typeArticleen_US

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