Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids
dc.contributor.author | Garnett, Graham A. E. | |
dc.contributor.author | Daze, Kevin D. | |
dc.contributor.author | Diaz, Jorge A. Pena | |
dc.contributor.author | Fagen, Noah | |
dc.contributor.author | Shaurya, Alok | |
dc.contributor.author | Ma, Manuel C. F. | |
dc.contributor.author | Collins, Mary S. | |
dc.contributor.author | Johnson, Darren W. | |
dc.contributor.author | Zakharov, Lev N. | |
dc.contributor.author | Hof, Fraser | |
dc.date.accessioned | 2020-11-02T21:08:59Z | |
dc.date.available | 2020-11-02T21:08:59Z | |
dc.date.copyright | 2016 | en_US |
dc.date.issued | 2016 | |
dc.description.abstract | We report a family of highly anionic calixarenes that form discrete homo-dimeric assemblies in pure water, that get stronger in high salt solutions, and that remain assembled in complex, denaturing solutions like real urine. The results reveal the potential of like-charged subunits for self-assembly in high-salt solutions and biological fluids. | en_US |
dc.description.reviewstatus | Reviewed | en_US |
dc.description.scholarlevel | Faculty | en_US |
dc.description.sponsorship | We thank Chris Barr for expert assistance with NMR experiments, and David Harrington for electrostatic potential energy calculations. This project was funded by NSERC Discovery Grant 326947. JPD was supported by a scholarship from MITACS. KD was supported by scholarships from WestCoast Ride to Live and Prostate Cancer Foundation of BC. FH is a Canada Research Chair. | en_US |
dc.identifier.citation | Garnett, G. A. E., Daze, K. D., Diaz, J. A. P., Fagen, N., Shaurya, A., Ma, M. C. F., … Hof, F. (2016). Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids. Chemical Communications, 52(13), 2768-2771. https://doi.org/10.1039/c5cc10527g | en_US |
dc.identifier.uri | https://doi.org/10.1039/c5cc10527g | |
dc.identifier.uri | http://hdl.handle.net/1828/12289 | |
dc.language.iso | en | en_US |
dc.publisher | Chemical Communications | en_US |
dc.subject.department | Department of Chemistry | |
dc.title | Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids | en_US |
dc.type | Article | en_US |