Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids

dc.contributor.authorGarnett, Graham A. E.
dc.contributor.authorDaze, Kevin D.
dc.contributor.authorDiaz, Jorge A. Pena
dc.contributor.authorFagen, Noah
dc.contributor.authorShaurya, Alok
dc.contributor.authorMa, Manuel C. F.
dc.contributor.authorCollins, Mary S.
dc.contributor.authorJohnson, Darren W.
dc.contributor.authorZakharov, Lev N.
dc.contributor.authorHof, Fraser
dc.date.accessioned2020-11-02T21:08:59Z
dc.date.available2020-11-02T21:08:59Z
dc.date.copyright2016en_US
dc.date.issued2016
dc.description.abstractWe report a family of highly anionic calixarenes that form discrete homo-dimeric assemblies in pure water, that get stronger in high salt solutions, and that remain assembled in complex, denaturing solutions like real urine. The results reveal the potential of like-charged subunits for self-assembly in high-salt solutions and biological fluids.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipWe thank Chris Barr for expert assistance with NMR experiments, and David Harrington for electrostatic potential energy calculations. This project was funded by NSERC Discovery Grant 326947. JPD was supported by a scholarship from MITACS. KD was supported by scholarships from WestCoast Ride to Live and Prostate Cancer Foundation of BC. FH is a Canada Research Chair.en_US
dc.identifier.citationGarnett, G. A. E., Daze, K. D., Diaz, J. A. P., Fagen, N., Shaurya, A., Ma, M. C. F., … Hof, F. (2016). Attraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluids. Chemical Communications, 52(13), 2768-2771. https://doi.org/10.1039/c5cc10527gen_US
dc.identifier.urihttps://doi.org/10.1039/c5cc10527g
dc.identifier.urihttp://hdl.handle.net/1828/12289
dc.language.isoenen_US
dc.publisherChemical Communicationsen_US
dc.titleAttraction by repulsion: compounds with like charges undergo self-assembly in water that improves in high salt and persists in real biological fluidsen_US
dc.typeArticleen_US

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