Recent segmental and gene duplications in the mouse genome

Date

2003-07

Authors

Cheung, Joseph
Wilson, Michael D
Zhang, Junjun
Khaja, Razi
MacDonald, Jeffrey R
Heng, Henry HQ
Koop, Ben F
Scherer, Stephen W

Journal Title

Journal ISSN

Volume Title

Publisher

Genome Biology

Abstract

Background: The high quality of the mouse genome draft sequence and its ssociated annotations are an invaluable biological resource. Identifying recent duplications in the mouse genome, especially in regions containing genes, may highlight important events in recent murine evolution. In addition, detecting recent sequence duplications can reveal potentially problematic regions of the genome assembly. We use BLAST-based computational heuristics to identify large (≥ 5 kb) and recent (≥ 90% sequence identity) segmental duplications in the mouse genome sequence. Here we present a database of recently duplicated regions of the mouse genome found in the mouse genome sequencing consortium (MGSC) February 2002 and February 2003 assemblies.

Description

BioMed Central

Keywords

sequencing, mouse genome

Citation

Cheung, J., Wilson, M., Zhang, J., Khaja, R., MacDonald, J., Heng, H., . . . Scherer, S. (2003). Recent segmental and gene duplications in the mouse genome. Genome Biology, 4(8), R47. Retrieved from http://genomebiology.com/2003/4/8/R47