Design of a thorium metal target for 225Ac production at TRIUMF
| dc.contributor.author | Robertson, Andrew K. H. | |
| dc.contributor.author | Lobbezoo, Andrew | |
| dc.contributor.author | Moskven, Louis | |
| dc.contributor.author | Schaffer, Paul | |
| dc.contributor.author | Hoehr, Cornelia | |
| dc.date.accessioned | 2022-12-03T00:15:02Z | |
| dc.date.available | 2022-12-03T00:15:02Z | |
| dc.date.copyright | 2019 | en_US |
| dc.date.issued | 2019 | |
| dc.description.abstract | With recent impressive clinical results of targeted alpha therapy using 225Ac, significant effort has been directed towards providing a reliable and sufficient supply of 225Ac to enable widespread using of 225Ac-radiopharmaceuticals. TRIUMF has begun production of 225Ac via spallation of thorium metal with 480 MeV protons. As part of this program, a new 225Ac-production target system capable of withstanding the power deposited by the proton beam was designed and its performance simulated over a range of potential operating parameters. Special attention was given to heat transfer and stresses within the target components. The target was successfully tested in two irradiations with a 72–73 μA proton beam for a duration of 36.5 h. The decay corrected activity at end of irradiation (average ± standard deviation) was (524 ± 21) MBq (14.2 mCi) and (86 ± 13) MBq (2.3 mCi) for 225Ac and 225Ra, respectively. These correspond to saturation yields of 72.5 MBq/μA for 225Ac and 17.6 MBq/μA for 225Ra. Longer irradiations and production scale-up are planned in the future. | en_US |
| dc.description.reviewstatus | Reviewed | en_US |
| dc.description.scholarlevel | Faculty | en_US |
| dc.description.sponsorship | TRIUMF receives funding via a contribution agreement with the National Research Council of Canada. | en_US |
| dc.identifier.citation | Robertson, A. K. H., Lobbezoo, A., Moskven, L., Schaeffer, P., & Hoehr, C. (2019). “Design of a thorium metal target for 225Ac production at TRIUMF.” Instruments, 3(1), 18. https://doi.org/10.3390/instruments3010018 | en_US |
| dc.identifier.uri | https://doi.org/10.3390/instruments3010018 | |
| dc.identifier.uri | http://hdl.handle.net/1828/14544 | |
| dc.language.iso | en | en_US |
| dc.publisher | Instruments | en_US |
| dc.subject | actinium-225 | |
| dc.subject | thorium | |
| dc.subject | spallation | |
| dc.subject | proton target | |
| dc.subject | ANSYS | |
| dc.subject | targeted alpha therapy | |
| dc.subject.department | Department of Physics and Astronomy | |
| dc.title | Design of a thorium metal target for 225Ac production at TRIUMF | en_US |
| dc.type | Article | en_US |