Droplet confinement and leakage: Causes, underlying effects, and amelioration strategies

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dc.contributor.authorDebon, Aaron P.
dc.contributor.authorWootton, Robert C.R.
dc.contributor.authorElvira, Katherine S.
dc.date.accessioned2018-10-16T22:58:43Z
dc.date.available2018-10-16T22:58:43Z
dc.date.copyright2015en_US
dc.date.issued2015
dc.description.abstractThe applicability of droplet-based microfluidic systems to many research fields stems from the fact that droplets are generally considered individual and selfcontained reaction vessels. This study demonstrates that, more often than not, the integrity of droplets is not complete, and depends on a range of factors including surfactant type and concentration, the micro-channel surface, droplet storage conditions, and the flow rates used to form and process droplets. Herein, a model microfluidic device is used for droplet generation and storage to allow the comparative study of forty-four different oil/surfactant conditions. Assessment of droplet stability under these conditions suggests a diversity of different droplet failure modes. These failure modes have been classified into families depending on the underlying effect, with both numerical and qualitative models being used to describe the causative effect and to provide practical solutions for droplet failure amelioration in microfluidic systems.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationDebon, A.P., Wootton, R.C.R. & Elvira, K.S. (2015). Droplet confinement and leakage: Causes, underlying effects, and amelioration strategies. Biomicrofluidics, 9(2), 024119. http://dx.doi.org/10.1063/1.4917343en_US
dc.identifier.urihttp://dx.doi.org/10.1063/1.4917343
dc.identifier.urihttp://hdl.handle.net/1828/10161
dc.language.isoenen_US
dc.publisherBiomicrofluidicsen_US
dc.subject.departmentDepartment of Chemistry
dc.titleDroplet confinement and leakage: Causes, underlying effects, and amelioration strategiesen_US
dc.typeArticleen_US

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