Electrostatically promoted dynamic hybridization of glucans with cationic polythiophene

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dc.contributor.authorFukuhara, Gaku
dc.contributor.authorImai, Mami
dc.contributor.authorIshida, Yuki
dc.contributor.authorKurohara, Hiroki
dc.contributor.authorYang, Cheng
dc.contributor.authorMori, Tadashi
dc.contributor.authorUyama, Hiroshi
dc.contributor.authorCornelia, Bohne
dc.contributor.authorInouea, Yoshihisa
dc.contributor.authorFuentealba, Denis
dc.date.accessioned2017-07-18T16:19:28Z
dc.date.copyright2016en_US
dc.date.issued2016
dc.description.abstractHybridizing natural macromolecule with synthetic polymer is an efficient general method for constructing sophisticated supramolecular architectures. To comprehensively elucidate the controversial hybridization mechanism of glucans with synthetic polymers, the hybridization behaviors of triple-stranded curdlan (Cur) and schizophyllan (SPG) with cationic polythiophene (PyPT) were investigated in aqueous DMSO solutions by using UV-vis, circular dichroism (CD), fluorescence, fluorescence excitation, and NMR spectroscopies, as well as theoretical calculations, dynamic light scattering, and zeta potential measurements. Upon mixing with glucan, a hetero-triplex formed was dynamic and greatly accelerated by heating and by adding base or salt. The hetero-triplex disassembled to hetero-duplex in highly basic solutions. Thus, polycationic polymers, such as PyPT, are expected to serve as a versatile tool for unzipping glucan homo-triplexes and promoting subsequent hybridization in aqueous solution, while the detailed mechanism elucidated in the present study contributes to the rational design of hybridization partners.en_US
dc.description.embargo2017-08-04
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by Grant-in-Aid for Young Scientists (B) (No. 23750129), Challenging Exploratory Research (No. 26620061), and Young Scientists (A) (No. 16H06041) for GF and Grant-in-Aid for Scientific Research (A) (No. 21245011) and Challenging Exploratory Research (No. 26620030) for YI, all from Japan Society for the Promotion of Science (JSPS), and also by the grants for GF from The Ogasawara Foundation for the Promotion of Science & Engineering and Nakatani Foundation. CB thanks the Natural Sciences and Engineering Research Council of Canada (NSERC) for financial support in the form of a Discovery Grant. CY thanks the National Natural Science Foundation of China for financial support (No. 21372165 and 23321061).en_US
dc.identifier.citationFukuhara, Gaku et al. (2016). Electrostatically promoted dynamic hybridization of glucans with cationic polythiophene. Organic & Biomolecular Chemistry, 14, 9741- 9750. doi 10.1039/C6OB01353Hen_US
dc.identifier.urihttps://doi.org/10.1039/C6OB01353H
dc.identifier.urihttp://hdl.handle.net/1828/8351
dc.language.isoenen_US
dc.publisherOrganic & Biomolecular Chemistryen_US
dc.subject.departmentDepartment of Chemistry
dc.titleElectrostatically promoted dynamic hybridization of glucans with cationic polythiopheneen_US
dc.typePostprinten_US

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