Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery
Date
2018
Authors
Skalamera, Dani
Matkovic, Marija
Uzelac, Lidija
Kralj, Marijeta
Mlinaric-Majerski, Kata
Bohne, Cornelia
Basaric, Nikola
Journal Title
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Volume Title
Publisher
Organic & Biomolecular Chemistry
Abstract
We demonstrate a proof of principle for a new approach in the development of a drug delivery system. A positively charged prodrug (phenol) can form a stable inclusion complex with CB[7], which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the complex, an active drug quinone methide (QM) is formed and released from the complex, since it is a neutral molecule and forms a less stable complex with CB[7].
Description
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Citation
Skalamera, D., Matkovic, M., Uzelac, Lidija, Kralj, M., Mlinaric-Majerski, K., Bohne, C., & Basaric, N. (2018). Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery. Organic & Biomolecular Chemistry, 16, 8908-8912. https://doi.org/10.1039/C8OB02605J.