Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

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dc.contributor.authorSkalamera, Dani
dc.contributor.authorMatkovic, Marija
dc.contributor.authorUzelac, Lidija
dc.contributor.authorKralj, Marijeta
dc.contributor.authorMlinaric-Majerski, Kata
dc.contributor.authorBohne, Cornelia
dc.contributor.authorBasaric, Nikola
dc.date.accessioned2020-08-14T19:03:09Z
dc.date.available2020-08-14T19:03:09Z
dc.date.copyright2018en_US
dc.date.issued2018
dc.description.abstractWe demonstrate a proof of principle for a new approach in the development of a drug delivery system. A positively charged prodrug (phenol) can form a stable inclusion complex with CB[7], which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the complex, an active drug quinone methide (QM) is formed and released from the complex, since it is a neutral molecule and forms a less stable complex with CB[7].en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThese materials are based on work financed by the Croatian Science Foundation (HRZZ, IP-2014-09-6312 and IP-2013-5660), the Natural Sciences and Engineering Research Council of Canada (CB, NSERC, RGPIN-121389-2012). NB thanks Professor P. Wan for financial support for the visit to UVIC. CB also thanks CAMTEC for the use of shared facilities.en_US
dc.identifier.citationSkalamera, D., Matkovic, M., Uzelac, Lidija, Kralj, M., Mlinaric-Majerski, K., Bohne, C., & Basaric, N. (2018). Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery. Organic & Biomolecular Chemistry, 16, 8908-8912. https://doi.org/10.1039/C8OB02605J.en_US
dc.identifier.urihttps://doi.org/10.1039/C8OB02605J
dc.identifier.urihttp://hdl.handle.net/1828/11994
dc.language.isoenen_US
dc.publisherOrganic & Biomolecular Chemistryen_US
dc.subject.departmentSchool of Earth and Ocean Sciences
dc.titlePhotodeamination to quinone methides in cucurbit[n]urils: potential application in drug deliveryen_US
dc.typePostprinten_US

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