The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis

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dc.contributor.authorSuarez-Ulloa, Victoria
dc.contributor.authorFernandez-Tajes, Juan
dc.contributor.authorAguiar-Pulido, Vanessa
dc.contributor.authorRivera-Casas, Ciro
dc.contributor.authorGonzalez-Romero, Rodrigo
dc.contributor.authorAusio, Juan
dc.contributor.authorMendez, Josefina
dc.contributor.authorDorado, Julian
dc.contributor.authorEirin-Lopez, Jose M.
dc.date.accessioned2020-10-05T20:24:34Z
dc.date.available2020-10-05T20:24:34Z
dc.date.copyright2013en_US
dc.date.issued2013
dc.description.abstractOkadaic Acid (OA) constitutes the main active principle in Diarrhetic Shellfish Poisoning (DSP) toxins produced during Harmful Algal Blooms (HABs), representing a serious threat for human consumers of edible shellfish. Furthermore, OA conveys critical deleterious effects for marine organisms due to its genotoxic potential. Many efforts have been dedicated to OA biomonitoring during the last three decades. However, it is only now with the current availability of detailed molecular information on DNA organization and the mechanisms involved in the maintenance of genome integrity, that a new arena starts opening up for the study of OA contamination. In the present work we address the links between OA genotoxicity and chromatin by combining Next Generation Sequencing (NGS) technologies and bioinformatics. To this end, we introduce CHROMEVALOAdb, a public database containing the chromatin-associated transcriptome of the mussel Mytilus galloprovincialis (a sentinel model organism) in response to OA exposure. This resource constitutes a leap forward for the development of chromatin-based biomarkers, paving the road towards the generation of powerful and sensitive tests for the detection and evaluation of the genotoxic effects of OA in coastal areas.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by grants awarded to J.M.E.-L by the Spanish Ministry of Economy and Competitivity (CGL2011-24812 & Ramon y Cajal Subprogramme), by the Xunta de Galicia (10-PXIB-103-077-PR) and by a fellowship from Campus do Mar (International Campus of Excellence). Partial support was also obtained from grants by the Spanish Ministry of Economy and Competitivity (AGL2008-05346, AGL2012-30897), by the Natural Sciences and Engineering Research Council of Canada (NSERC-46399-12) and by the Xunta de Galicia (CN2012/127). V.A.-P. was supported by the ―Plan I2C‖ (Xunta de Galicia) and the European Social Fund (ESF). C.R.-C. and R.G.-R. are recipients of FPU and Postdoctoral fellowships from the Spanish Ministry of Education, respectively. We thank the editors and two anonymous reviewers for their constructive comments, which helped us to improve the final version of the manuscript.en_US
dc.identifier.citationSuárez-Ulloa, V., Fernández-Tajes, J., Aguiar-Pulido, V., Rivera-Casas, C., González-Romero, R., Ausio, J., Méndez, J., Dorado, J., & Eirín-López, J. M. (2013). The CHROMEOVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Musen_US
dc.identifier.urihttps://doi.org/10.3390/axioms1030238
dc.identifier.urihttp://hdl.handle.net/1828/12172
dc.language.isoenen_US
dc.publisherMarine Drugsen_US
dc.subjectokadaic acid
dc.subjectHarmful Algae Blooms
dc.subjectmussels
dc.subjectchromatin
dc.subjectdatabase
dc.subjectMytilus galloprovincialis
dc.subject.departmentDepartment of Mathematics and Statistics
dc.titleThe CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialisen_US
dc.typeArticleen_US

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