Recent advances in the design of microfluidic technologies for the manufacture of drug releasing particles
Date
2021
Authors
Forigua, Alejandro
Kirsch, Rebecca L.
Willerth, Stephanie M.
Elvira, Katherine S.
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Controlled Release
Abstract
Drug releasing particles are valued for their ability to deliver therapeutics to targeted locations and for their controllable release patterns. The development of microfluidic technologies, which are designed specifically to manipulate small amounts of fluids, to manufacture particles for drug delivery applications reflects a recent trend due to the advantages they confer in terms of control over particle size and material composition. This review takes a comprehensive look at the different types of microfluidic devices used to fabricate such particles from different types of biomaterials, and at how the on-chip features enable the production of particles with different types of properties. The review concludes by suggesting avenues for future work that will enable these technologies to fulfill their potential and be used in industrial settings for the manufacture of drug releasing particles with unique capabilities.
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Citation
Forigua, A., Kirsch, R. L., Willerth, S. M., & Elvira, K. S. (2021). Recent advances in the design of microfluidic technologies for the manufacture of drug releasing particles. Journal of Controlled Release, 333, 258–268. https://doi.org/10.1016/j.jconrel.2021.03.019