Recent advances in the design of microfluidic technologies for the manufacture of drug releasing particles
| dc.contributor.author | Forigua, Alejandro | |
| dc.contributor.author | Kirsch, Rebecca L. | |
| dc.contributor.author | Willerth, Stephanie M. | |
| dc.contributor.author | Elvira, Katherine S. | |
| dc.date.accessioned | 2024-11-04T19:08:32Z | |
| dc.date.available | 2024-11-04T19:08:32Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Drug releasing particles are valued for their ability to deliver therapeutics to targeted locations and for their controllable release patterns. The development of microfluidic technologies, which are designed specifically to manipulate small amounts of fluids, to manufacture particles for drug delivery applications reflects a recent trend due to the advantages they confer in terms of control over particle size and material composition. This review takes a comprehensive look at the different types of microfluidic devices used to fabricate such particles from different types of biomaterials, and at how the on-chip features enable the production of particles with different types of properties. The review concludes by suggesting avenues for future work that will enable these technologies to fulfill their potential and be used in industrial settings for the manufacture of drug releasing particles with unique capabilities. | |
| dc.description.reviewstatus | Reviewed | |
| dc.description.scholarlevel | Faculty | |
| dc.description.sponsorship | Dr. Willerth receives funding from the NSERC Discovery Grant program, the Canada Research Chairs program, the Michael Smith Foundation for Health Research and the Pacific Parkinson's Research Institute. Dr. Elvira receives funding from the Canada Research Chairs program, and the Michael Smith Foundation for Health Research Scholar program in partnership with the Pacific Alzheimer Research Foundation. Alejandro Forigua is funded through Dr. Elvira's NSERC Discovery Grant. | |
| dc.identifier.citation | Forigua, A., Kirsch, R. L., Willerth, S. M., & Elvira, K. S. (2021). Recent advances in the design of microfluidic technologies for the manufacture of drug releasing particles. Journal of Controlled Release, 333, 258–268. https://doi.org/10.1016/j.jconrel.2021.03.019 | |
| dc.identifier.uri | https://doi.org/10.1016/j.jconrel.2021.03.019 | |
| dc.identifier.uri | https://hdl.handle.net/1828/20727 | |
| dc.language.iso | en | |
| dc.publisher | Journal of Controlled Release | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.department | Department of Chemistry | |
| dc.subject.department | Department of Mechanical Engineering | |
| dc.subject.department | Division of Medical Sciences | |
| dc.subject.department | School of Medical Sciences | |
| dc.title | Recent advances in the design of microfluidic technologies for the manufacture of drug releasing particles | |
| dc.type | Postprint |