Biodegradable elastic nanofibrous platforms with integrated flexible heaters for ondemand drug delivery




Tamayol, Ali
Najafabadi, Alirez Hassani
Mostafalu, Pooria
Yetisen, Ali K.
Commotto, Mattia
Aldhahri, Musab
Abdel-wahab, Mohamed Shaaban
Zeynab Izadi, Najafabadi
Latifi, Shahrzad
Akbari, Mohsen

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Scientific Reports


Delivery of drugs with controlled temporal profiles is essential for wound treatment and regenerative medicine applications. For example, bacterial infection is a key challenge in the treatment of chronic and deep wounds. Current treatment strategies are based on systemic administration of high doses of antibiotics, which result in side effects and drug resistance. On-demand delivery of drugs with controlled temporal profile is highly desirable. Here, we have developed thermally controllable, antibiotic-releasing nanofibrous sheets. Poly(glycerol sebacate)-poly(caprolactone) (PGS-PCL) blends were electrospun to form elastic polymeric sheets with fiber diameters ranging from 350 to 1100 nm and substrates with a tensile modulus of approximately 4-8 MPa. A bioresorbable metallic heater was patterned directly on the nanofibrous substrate for applying thermal stimulation to release antibiotics on-demand. In vitro studies confirmed the platform's biocompatibility and biodegradability. The released antibiotics were potent against tested bacterial strains. These results may pave the path toward developing electronically controllable wound dressings that can deliver drugs with desired temporal patterns.




Tamayol, A.; Njafabadi, A.H.; Mostafalu, P.; Yetisen, A.K.; Commotto, M.; Aldhahri, M.; … & Khademhosseini, A. (2017). Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery. Scientific Reports, 7, article 9220. DOI: 10.1038/s41598-017-04749-8