Biodegradable elastic nanofibrous platforms with integrated flexible heaters for ondemand drug delivery

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dc.contributor.authorTamayol, Ali
dc.contributor.authorNajafabadi, Alirez Hassani
dc.contributor.authorMostafalu, Pooria
dc.contributor.authorYetisen, Ali K.
dc.contributor.authorCommotto, Mattia
dc.contributor.authorAldhahri, Musab
dc.contributor.authorAbdel-wahab, Mohamed Shaaban
dc.contributor.authorZeynab Izadi, Najafabadi
dc.contributor.authorLatifi, Shahrzad
dc.contributor.authorAkbari, Mohsen
dc.contributor.authorAnnabi, Nasim
dc.contributor.authorYun, Seok Hyun
dc.contributor.authorMemic, Adnan
dc.contributor.authorDokmeci, Mehmet R.
dc.contributor.authorKhademhosseini, Ali
dc.date.accessioned2018-12-19T03:27:09Z
dc.date.available2018-12-19T03:27:09Z
dc.date.copyright2017en_US
dc.date.issued2017
dc.description.abstractDelivery of drugs with controlled temporal profiles is essential for wound treatment and regenerative medicine applications. For example, bacterial infection is a key challenge in the treatment of chronic and deep wounds. Current treatment strategies are based on systemic administration of high doses of antibiotics, which result in side effects and drug resistance. On-demand delivery of drugs with controlled temporal profile is highly desirable. Here, we have developed thermally controllable, antibiotic-releasing nanofibrous sheets. Poly(glycerol sebacate)-poly(caprolactone) (PGS-PCL) blends were electrospun to form elastic polymeric sheets with fiber diameters ranging from 350 to 1100 nm and substrates with a tensile modulus of approximately 4-8 MPa. A bioresorbable metallic heater was patterned directly on the nanofibrous substrate for applying thermal stimulation to release antibiotics on-demand. In vitro studies confirmed the platform's biocompatibility and biodegradability. The released antibiotics were potent against tested bacterial strains. These results may pave the path toward developing electronically controllable wound dressings that can deliver drugs with desired temporal patterns.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis work was supported by National Science Foundation (EFRI-1240443), the Office of Naval Research Young Investigator award, ONR PECASE Award, and the National Institutes of Health (HL092836, DE019024, EB012597, AR057837, DE021468, HL099073, EB008392). This project was funded by the National Plan for Science, Technology and Innovation (MAARIFAH) - King Abdulaziz City for Science and Technology - the Kingdom of Saudi Arabia - award number (12-MED3096-3). The authors also, acknowledge with thanks Science and Technology Unit, King Abdulaziz University. This work was also supported by the Scientific WAQF Fund at King Abdulaziz University (KAU), Jeddah under grant number 17/1436. N.A. acknowledges the support from the American Heart Association (AHA, 16SDG31280010), FY17 TIER 1 Interdisciplinary Research Seed Grants from Northeastern University, and the startup fund provided by the Department of Chemical Engineering, College of Engineering at Northeastern University.en_US
dc.identifier.citationTamayol, A.; Njafabadi, A.H.; Mostafalu, P.; Yetisen, A.K.; Commotto, M.; Aldhahri, M.; … & Khademhosseini, A. (2017). Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery. Scientific Reports, 7, article 9220. DOI: 10.1038/s41598-017-04749-8en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-017-04749-8
dc.identifier.urihttp://hdl.handle.net/1828/10419
dc.language.isoenen_US
dc.publisherScientific Reportsen_US
dc.subject.departmentDepartment of Mechanical Engineering
dc.titleBiodegradable elastic nanofibrous platforms with integrated flexible heaters for ondemand drug deliveryen_US
dc.typeArticleen_US

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