The role of dopamine receptors in lymphocytes and their changes in schizophrenia
Date
2021
Authors
Penedo, M. A.
Rivera-Baltanás, T.
Pérez-Rodríguez, D.
Allen, J.
Borrajo, A.
Alonso-Crespo, D.
Fernandez-Pereira, C.
Nieto-Araujo, M.
Ramos-García, S.
Barreiro-Villar, C.
Journal Title
Journal ISSN
Volume Title
Publisher
Brain, Behavior, & Immunity – Health
Abstract
Dopamine and its 5 receptors, which are grouped into two families (D1-like and D2-like), modulate functions at a systemic level in both the central nervous system and periphery. The central nervous system and the immune system are the main adaptive systems, which participate in a continuous and functional crosstalk to guarantee homeostasis. On binding to its 5 dopamine receptors, dopamine acts as a co-regulator of the immune system, contributing to the interaction of the central nervous system and inflammatory events and as a source of communication between the different immune cells. Dopaminergic perturbations in the central nervous system are observed in several neurological and psychiatric disorders. Schizophrenia is one of the most common mental disorders with a poorly understood pathoaetiology that includes genetic and environmental components that promote alterations in the dopaminergic system. Interestingly, abnormalities in dopamine receptors expression in lymphocytes of schizophrenia patients have been reported, often significantly correlating with the severity of the psychotic illness. Here, we review the current literature regarding the dopaminergic system in human lymphocytes and its alterations in schizophrenia.
Description
Keywords
Schizophrenia, Psychosis, Dopamine, Dopamine receptors, Lymphocytes
Citation
Penedo, M. A., Rivera-Baltanás, T., Pérez-Rodríguez, D., Allen, J., Borrajo, A., Alonso- Crespo, D., … Agís-Balboa, R. C. (2021). The role of dopamine receptors in lymphocytes and their changes in schizophrenia. Brain, Behavior, & Immunity – Health, 12, 1-10. https://doi.org/10.1016/j.bbih.2021.100199.