The role of dopamine receptors in lymphocytes and their changes in schizophrenia

dc.contributor.authorPenedo, M. A.
dc.contributor.authorRivera-Baltanás, T.
dc.contributor.authorPérez-Rodríguez, D.
dc.contributor.authorAllen, J.
dc.contributor.authorBorrajo, A.
dc.contributor.authorAlonso-Crespo, D.
dc.contributor.authorFernandez-Pereira, C.
dc.contributor.authorNieto-Araujo, M.
dc.contributor.authorRamos-García, S.
dc.contributor.authorBarreiro-Villar, C.
dc.contributor.authorCaruncho, H. J.
dc.contributor.authorOlivares, J. M.
dc.contributor.authorAgís-Balboa, R. C.
dc.date.accessioned2021-03-01T23:31:30Z
dc.date.available2021-03-01T23:31:30Z
dc.date.copyright2021en_US
dc.date.issued2021
dc.description.abstractDopamine and its 5 receptors, which are grouped into two families (D1-like and D2-like), modulate functions at a systemic level in both the central nervous system and periphery. The central nervous system and the immune system are the main adaptive systems, which participate in a continuous and functional crosstalk to guarantee homeostasis. On binding to its 5 dopamine receptors, dopamine acts as a co-regulator of the immune system, contributing to the interaction of the central nervous system and inflammatory events and as a source of communication between the different immune cells. Dopaminergic perturbations in the central nervous system are observed in several neurological and psychiatric disorders. Schizophrenia is one of the most common mental disorders with a poorly understood pathoaetiology that includes genetic and environmental components that promote alterations in the dopaminergic system. Interestingly, abnormalities in dopamine receptors expression in lymphocytes of schizophrenia patients have been reported, often significantly correlating with the severity of the psychotic illness. Here, we review the current literature regarding the dopaminergic system in human lymphocytes and its alterations in schizophrenia.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThe authors would like to thank Galicia Sur Health Research Institute and the Área Sanitaria de Vigo for their support. We especially thank the Psychiatric Nursing Service and Psychiatrists at the Álvaro Cunqueiro Hospital and Nicolás Peña Hospital.en_US
dc.identifier.citationPenedo, M. A., Rivera-Baltanás, T., Pérez-Rodríguez, D., Allen, J., Borrajo, A., Alonso- Crespo, D., … Agís-Balboa, R. C. (2021). The role of dopamine receptors in lymphocytes and their changes in schizophrenia. Brain, Behavior, & Immunity – Health, 12, 1-10. https://doi.org/10.1016/j.bbih.2021.100199.en_US
dc.identifier.urihttps://doi.org/10.1016/j.bbih.2021.100199
dc.identifier.urihttp://hdl.handle.net/1828/12733
dc.language.isoenen_US
dc.publisherBrain, Behavior, & Immunity – Healthen_US
dc.subjectSchizophreniaen_US
dc.subjectPsychosisen_US
dc.subjectDopamineen_US
dc.subjectDopamine receptorsen_US
dc.subjectLymphocytesen_US
dc.titleThe role of dopamine receptors in lymphocytes and their changes in schizophreniaen_US
dc.typeArticleen_US

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