History of brain injury alters cerebral haemodynamic oscillations with cardiac influence
Date
2022
Authors
Neary, J. Patrick
Singh, Jyotpal
Sirant, Luke W.
Gaul, Catherine A.
Martin, Steve
Stuart-Hill, Lynneth
Candow, Darren G.
Mang, Cameron S.
Kratzig, Gregory P.
Journal Title
Journal ISSN
Volume Title
Publisher
Brain Sciences
Abstract
(1) Background: Cerebral autoregulation is altered during acute mild traumatic brain injury,
or concussion. However, it is unknown how a history of concussion can impact cerebral haemodynamic
activity during a task that elicits an autoregulatory response. (2) Methods: We assessed
cerebral haemodynamic activity in those with a history of three or more concussions. The study
included 44 retired athletes with concussion history and 25 control participants. We recorded participants’
relative changes in right and left pre‐frontal cortex oxygenation collected by near‐infrared
spectroscopy and continuous beat‐to‐beat blood pressure measured by finger photoplethysmography.
Participants completed a 5‐min seated rest followed by a 5‐min repeated squat (10‐s) stand (10‐
s) maneuver (0.05 Hz) to elicit a cerebral autoregulatory response. Wavelet transformation was applied
to the collected signals, allowing separation into cardiac interval I (0.6 to 2 Hz), respiratory
interval II (0.145 to 0.6 Hz), and smooth muscle cell interval III (0.052 to 0.145 Hz). (3) Results: Significant
increases at cardiac interval I were found for the wavelet amplitude of oxy‐haemoglobin
and haemoglobin difference at the right pre‐frontal cortex. No significant difference was found at
the left pre‐frontal cortex or the blood pressure wavelet amplitudes. (4) Conclusion: Contributions
from cardiac activity to the pre‐frontal cortex oxygenation are elevated when eliciting dynamic cerebral
autoregulation in those with a history of three or more concussions.
Description
Keywords
concussion, cerebral autoregulation, pre-frontal cortex oxygenation, blood pressure, wavelet transformation
Citation
Neary, J. P., Singh, J., Sirant, L. W., Gaul, C. A., Martin, S., Stuart-Hill, L., . . . Kratzig, G. P. (2022). “History of brain injury alters cerebral haemodynamic oscillations with cardiac influence.” Brain Sciences, 12(11), 1443. https://doi.org/10.3390/brainsci12111443