History of brain injury alters cerebral haemodynamic oscillations with cardiac influence

dc.contributor.authorNeary, J. Patrick
dc.contributor.authorSingh, Jyotpal
dc.contributor.authorSirant, Luke W.
dc.contributor.authorGaul, Catherine A.
dc.contributor.authorMartin, Steve
dc.contributor.authorStuart-Hill, Lynneth
dc.contributor.authorCandow, Darren G.
dc.contributor.authorMang, Cameron S.
dc.contributor.authorKratzig, Gregory P.
dc.date.accessioned2022-11-12T14:44:02Z
dc.date.available2022-11-12T14:44:02Z
dc.date.copyright2022en_US
dc.date.issued2022
dc.description.abstract(1) Background: Cerebral autoregulation is altered during acute mild traumatic brain injury, or concussion. However, it is unknown how a history of concussion can impact cerebral haemodynamic activity during a task that elicits an autoregulatory response. (2) Methods: We assessed cerebral haemodynamic activity in those with a history of three or more concussions. The study included 44 retired athletes with concussion history and 25 control participants. We recorded participants’ relative changes in right and left pre‐frontal cortex oxygenation collected by near‐infrared spectroscopy and continuous beat‐to‐beat blood pressure measured by finger photoplethysmography. Participants completed a 5‐min seated rest followed by a 5‐min repeated squat (10‐s) stand (10‐ s) maneuver (0.05 Hz) to elicit a cerebral autoregulatory response. Wavelet transformation was applied to the collected signals, allowing separation into cardiac interval I (0.6 to 2 Hz), respiratory interval II (0.145 to 0.6 Hz), and smooth muscle cell interval III (0.052 to 0.145 Hz). (3) Results: Significant increases at cardiac interval I were found for the wavelet amplitude of oxy‐haemoglobin and haemoglobin difference at the right pre‐frontal cortex. No significant difference was found at the left pre‐frontal cortex or the blood pressure wavelet amplitudes. (4) Conclusion: Contributions from cardiac activity to the pre‐frontal cortex oxygenation are elevated when eliciting dynamic cerebral autoregulation in those with a history of three or more concussions.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipFunding from the Canadian Academy of Sport and Exercise Medicine (CASEM) is gratefully acknowledged.en_US
dc.identifier.citationNeary, J. P., Singh, J., Sirant, L. W., Gaul, C. A., Martin, S., Stuart-Hill, L., . . . Kratzig, G. P. (2022). “History of brain injury alters cerebral haemodynamic oscillations with cardiac influence.” Brain Sciences, 12(11), 1443. https://doi.org/10.3390/brainsci12111443en_US
dc.identifier.urihttps://doi.org/10.3390/brainsci12111443
dc.identifier.urihttp://hdl.handle.net/1828/14414
dc.language.isoenen_US
dc.publisherBrain Sciencesen_US
dc.subjectconcussionen_US
dc.subjectcerebral autoregulationen_US
dc.subjectpre-frontal cortex oxygenationen_US
dc.subjectblood pressureen_US
dc.subjectwavelet transformationen_US
dc.titleHistory of brain injury alters cerebral haemodynamic oscillations with cardiac influenceen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Gaul_Catherine_BrainSci_2022.pdf
Size:
667.56 KB
Format:
Adobe Portable Document Format
Description:
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2 KB
Format:
Item-specific license agreed upon to submission
Description: