Toward increased reliability, transparency, and accessibility in cross-linking mass spectrometry

dc.contributor.authorLeitner, Alexander
dc.contributor.authorBonvin, Alexandre M. J. J.
dc.contributor.authorBorchers, Christoph H.
dc.contributor.authorChalkley, Robert J.
dc.contributor.authorChamot-Rooke, Julia
dc.contributor.authorCombe, Colin W.
dc.contributor.authorCox, Jürgen
dc.contributor.authorDong, Meng-Qiu
dc.contributor.authorFischer, Lutz
dc.contributor.authorGötze, Michael
dc.contributor.authorGozzo, Fabio C.
dc.contributor.authorHeck, Albert J. R.
dc.contributor.authorHoopmann, Michael R.
dc.contributor.authorHuang, Lan
dc.contributor.authorIshihama, Yasushi
dc.contributor.authorJones, Andrew R.
dc.contributor.authorKalisman, Nir
dc.contributor.authorKohlbacher, Oliver
dc.contributor.authorMechtler, Karl
dc.contributor.authorMoritz, Robert L.
dc.contributor.authorNetz, Eugen
dc.contributor.authorNovak, Petr
dc.contributor.authorPetrotchenko, Evgeniy
dc.contributor.authorSali, Andrej
dc.contributor.authorScheltema, Richard A.
dc.contributor.authorSchmidt, Carla
dc.contributor.authorSchriemer, David
dc.contributor.authorSinz, Andrea
dc.contributor.authorSobott, Frank
dc.contributor.authorStengel, Florian
dc.contributor.authorThalassinos, Konstantinos
dc.contributor.authorUrlaub, Henning
dc.contributor.authorViner, Rosa
dc.contributor.authorVizcaíno, Juan A.
dc.contributor.authorWilkins, Marc R.
dc.contributor.authorRappsilber, Juri
dc.date.accessioned2024-03-12T15:26:22Z
dc.date.available2024-03-12T15:26:22Z
dc.date.issued2020
dc.description.abstractCross-linking mass spectrometry (MS) has substantially matured as a method over the past 2 decades through parallel development in multiple labs, demonstrating its applicability to protein structure determination, conformation analysis, and mapping protein interactions in complex mixtures. Cross-linking MS has become a much-appreciated and routinely applied tool, especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Cross-linking MS for which guidelines should be developed as part of a Cross-linking MS standards initiative.
dc.description.reviewstatusReviewed
dc.description.scholarlevelFaculty
dc.description.sponsorshipThis work was supported by the Wellcome Trust through a Senior Research Fellowship to J.R. (103139) and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, project 329673113). Funded by the DFG under Germany's Excellence Strategy, EXC 2008/1-390540038. The Wellcome Centre for Cell Biology is supported by core funding from the Wellcome Trust (203149).
dc.identifier.citationLeitner, A., Bonvin, A. M. J. J., Borchers, C. H., Chalkley, R. J., Chamot‐Rooke, J., Combe, C., Cox, J., Dong, M., Fischer, L., Gøtze, M., Gozzo, F. C., Heck, A. J. R., Hoopmann, M. R., Huang, L., Ishihama, Y., Jones, A. R., Kalisman, N., Kohlbacher, O., Mechtler, K., . . . Rappsilber, J. (2020). Toward increased reliability, transparency, and accessibility in cross-linking mass spectrometry. Structure, 28(11), 1259–1268. https://doi.org/10.1016/j.str.2020.09.011
dc.identifier.urihttps://doi.org/10.1016/j.str.2020.09.011
dc.identifier.urihttps://hdl.handle.net/1828/16060
dc.language.isoen
dc.publisherStructure
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleToward increased reliability, transparency, and accessibility in cross-linking mass spectrometry
dc.typeArticle

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