Neural tissue engineering using embryonic and induced pluripotent stem cells

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dc.contributor.authorWillerth, Stephanie
dc.date.accessioned2014-06-04T22:02:53Z
dc.date.available2014-06-04T22:02:53Z
dc.date.copyright2011en_US
dc.date.issued2011-04-15
dc.descriptionBioMed Centralen_US
dc.description.abstractWith the recent start of the first clinical trial evaluating a human embryonic stem cell-derived therapy for the treatment of acute spinal cord injury, it is important to review the current literature examining the use of embryonic stem cells for neural tissue engineering applications with a focus on diseases and disorders that affect the central nervous system. Embryonic stem cells exhibit pluripotency and thus can differentiate into any cell type found in the body, including those found in the nervous system. A range of studies have investigated how to direct the differentiation of embryonic cells into specific neural phenotypes using a variety of cues to achieve the goal of replacing diseased or damaged neural tissue. Additionally, the recent development of induced pluripotent stem cells provides an intriguing alternative to the use of human embryonic stem cell lines for these applications. This review will discuss relevant studies that have used embryonic stem cells to replicate the tissue found in the central nervous system as well as evaluate the potential of induced pluripotent stem cells for the aforementioned applications.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.identifier.citationWillerth SM: Neural tissue engineering using embryonic and induced pluripotent stem cells. Stem Cell Research & Therapy 2011, 2:17.en_US
dc.identifier.urihttp://stemcellres.com/content/2/2/17
dc.identifier.urihttp://dx.doi.org/10.1186/scrt58
dc.identifier.urihttp://hdl.handle.net/1828/5428
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.subject.departmentDepartment of Mechanical Engineering
dc.subject.departmentSchool of Medical Sciences
dc.titleNeural tissue engineering using embryonic and induced pluripotent stem cellsen_US
dc.typeArticleen_US

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