Are Neurocognitive Speed and Inconsistency Similarly Affected in Type 2 Diabetes?
Date
2011
Authors
Whitehead, B.P.
Dixon, R.A.
Hultsch, D.F.
MacDonald, S.W.S.
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Clinical and Experimental Neuropsychology
Abstract
Type 2 diabetes (T2D) is a disease of aging with indirect but detectable and cumulative neurological implications. We systematically tested whether neurocognitive speed (mean rate) or inconsistency (intraindividual variability) was the more sensitive clinical marker of T2D. Three of four research questions used a cross-sectional wave of the Victoria Longitudinal Study (VLS) divided into T2D (age 55-81 years) and control (age = 53-91 years) groups. The fourth question addressed relative two-wave longitudinal changes. Each of four speeded tasks produced intraindividual mean rate (IM) and intraindividual standard deviation (ISD) scores. First, the T2D group performed more slowly than the controls. Second, this deficit extended to inconsistency, but less uniformly. Third, based on logistic regression analyses, IM was the more effective predictor of T2D status. Fourth, we observed similar longitudinal change patterns for IM and ISD. Results are linked to the theoretical location of T2D on an adjusted neural vulnerability continuum.
Description
Keywords
Aging, Intraindividual Variability, Logistic Regression Analyses, Neurocognitive Speed, Type 2 Diabetes, Victoria Longitudinal Study
Citation
Whitehead, B.P., Dixon, R.A., Hultsch, D.F., MacDonald, S.W.S. (2011). Are Neurocognitive Speed and Inconsistency Similarly Affected in Type 2 Diabetes? Journal of Clinical and Experimental Neuropsychology, 33(6), 647-657. https://doi.org/10.1080/13803395.2010.547845