Are Neurocognitive Speed and Inconsistency Similarly Affected in Type 2 Diabetes?

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dc.contributor.authorWhitehead, B.P.
dc.contributor.authorDixon, R.A.
dc.contributor.authorHultsch, D.F.
dc.contributor.authorMacDonald, S.W.S.
dc.date.accessioned2021-10-01T21:14:49Z
dc.date.available2021-10-01T21:14:49Z
dc.date.copyright2011en_US
dc.date.issued2011
dc.description.abstractType 2 diabetes (T2D) is a disease of aging with indirect but detectable and cumulative neurological implications. We systematically tested whether neurocognitive speed (mean rate) or inconsistency (intraindividual variability) was the more sensitive clinical marker of T2D. Three of four research questions used a cross-sectional wave of the Victoria Longitudinal Study (VLS) divided into T2D (age 55-81 years) and control (age = 53-91 years) groups. The fourth question addressed relative two-wave longitudinal changes. Each of four speeded tasks produced intraindividual mean rate (IM) and intraindividual standard deviation (ISD) scores. First, the T2D group performed more slowly than the controls. Second, this deficit extended to inconsistency, but less uniformly. Third, based on logistic regression analyses, IM was the more effective predictor of T2D status. Fourth, we observed similar longitudinal change patterns for IM and ISD. Results are linked to the theoretical location of T2D on an adjusted neural vulnerability continuum.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThis research was supported by a grant from the U.S. National Institutes of Health (National Institute on Aging) to Roger A. Dixon (R37 AG008235). Dr. Dixon is also supported by the Canadian Research Chairs program. We appreciate the many important contributions of VLS participants and staff (notably Ashley Fischer, Jill Friesen, and Terry Perkins) to the present research. Contact author is Roger Dixon: rdixon@ualberta.ca. Further information about the VLS may be accessed via: http://www.ualberta.ca/~vlslab/index.htmlen_US
dc.identifier.citationWhitehead, B.P., Dixon, R.A., Hultsch, D.F., MacDonald, S.W.S. (2011). Are Neurocognitive Speed and Inconsistency Similarly Affected in Type 2 Diabetes? Journal of Clinical and Experimental Neuropsychology, 33(6), 647-657. https://doi.org/10.1080/13803395.2010.547845en_US
dc.identifier.urihttps://doi.org/10.1080/13803395.2010.547845
dc.identifier.urihttp://hdl.handle.net/1828/13427
dc.language.isoenen_US
dc.publisherJournal of Clinical and Experimental Neuropsychologyen_US
dc.subjectAging
dc.subjectIntraindividual Variability
dc.subjectLogistic Regression Analyses
dc.subjectNeurocognitive Speed
dc.subjectType 2 Diabetes
dc.subjectVictoria Longitudinal Study
dc.subject.departmentDepartment of Psychology
dc.titleAre Neurocognitive Speed and Inconsistency Similarly Affected in Type 2 Diabetes?en_US
dc.typeArticleen_US

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