A Rigid Bicyclic Platform for the Generation of Conformationally Locked Neuraminidase Inhibitors

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Brant_Michael_OrgLett_2012.pdf (1.52 MB)

Date

2012

Authors

Brant, Michael G.
Wulff, Jeremy E.

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Volume Title

Publisher

Organic Letters

Abstract

Rapid mutation of the influenza virus through genetic mixing raises the prospect of new strains that are both highly transmissible and highly lethal, and which have the ability to evade both immunization strategies (through mutation of hemagglutinin) and current therapies (through mutation of neuraminidase). Inspired by a need for next-generation therapeutics, a synthetic strategy for a new class of rigid, bicyclic inhibitors of influenza neuraminidase is reported.

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Citation

Brant, M. G. & Wulff, J. E. (2012). A rigid bicyclic platform for the generation of conformationally locked neuraminidase inhibitors. Organic Letters, 14(23), 5876-5879. https://doi.org/10.1021/ol3027939

URI

https://doi.org/10.1021/ol3027939
 http://hdl.handle.net/1828/11868

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