A Rigid Bicyclic Platform for the Generation of Conformationally Locked Neuraminidase Inhibitors
| dc.contributor.author | Brant, Michael G. | |
| dc.contributor.author | Wulff, Jeremy E. | |
| dc.date.accessioned | 2020-06-21T13:30:52Z | |
| dc.date.available | 2020-06-21T13:30:52Z | |
| dc.date.copyright | 2012 | en_US |
| dc.date.issued | 2012 | |
| dc.description.abstract | Rapid mutation of the influenza virus through genetic mixing raises the prospect of new strains that are both highly transmissible and highly lethal, and which have the ability to evade both immunization strategies (through mutation of hemagglutinin) and current therapies (through mutation of neuraminidase). Inspired by a need for next-generation therapeutics, a synthetic strategy for a new class of rigid, bicyclic inhibitors of influenza neuraminidase is reported. | en_US |
| dc.description.reviewstatus | Reviewed | en_US |
| dc.description.scholarlevel | Faculty | en_US |
| dc.description.sponsorship | We thank the Canadian Institutes of Health Research for funding and Dr. Martin Petric (BC Centre for Disease Control) for a sample of inactivated influenza virus. We also thank Dr. Allen Oliver (University of Notre Dame) for X-ray analysis, Dr. Martin Boulanger (UVic Biochemistry) for helpful discussions, and the UVic Genome BC Proteomics Centre for mass spectrometry support. | en_US |
| dc.identifier.citation | Brant, M. G. & Wulff, J. E. (2012). A rigid bicyclic platform for the generation of conformationally locked neuraminidase inhibitors. Organic Letters, 14(23), 5876-5879. https://doi.org/10.1021/ol3027939 | en_US |
| dc.identifier.uri | https://doi.org/10.1021/ol3027939 | |
| dc.identifier.uri | http://hdl.handle.net/1828/11868 | |
| dc.language.iso | en | en_US |
| dc.publisher | Organic Letters | en_US |
| dc.subject.department | Department of Chemistry | |
| dc.title | A Rigid Bicyclic Platform for the Generation of Conformationally Locked Neuraminidase Inhibitors | en_US |
| dc.type | Article | en_US |