Mechanism of a disassembly-driven sensing system studied by stopped-flow kinetics

Simple item page
dc.contributor.authorGallo, Cara
dc.contributor.authorThomas, Suma S.
dc.contributor.authorSelinger, Allison J.
dc.contributor.authorHof, Fraser
dc.contributor.authorBohne, Cornelia
dc.date.accessioned2023-01-13T18:59:01Z
dc.date.available2023-01-13T18:59:01Z
dc.date.copyright2021en_US
dc.date.issued2021
dc.description.abstractWe carried out steady-state and stopped-flow photophysical measurements to determine the kinetics of a discrete disassembly driven turn-on fluorescent system. On and off rates for both DimerDye1 (DD1) assembly, and nicotine binding were determined. Relative rates for these competing processes provide insight on how this system can be optimized for sensing applications. Kinetics studies in artificial saliva showed that moving to more complex media has minimal effects on the sensing ability of the system.en_US
dc.description.reviewstatusRevieweden_US
dc.description.scholarlevelFacultyen_US
dc.description.sponsorshipThe authors thank the Natural Sciences and Engineering Research Council of Canada (NSERC) for financial support (CB-RGPIN-2017-04458; FH-RGPIN-2019-04806) and CAMTEC for the use of shared facilities.en_US
dc.identifier.citationGallo, C., Thomas, S. S., Selinger, A. J., Hof, F., & Bohne, C. (2021). Mechanism of a disassembly-driven sensing system studied by stopped-flow kinetics. The Journal of Organic Chemistry, 86(15), 10782-10787. https://doi.org/10.1021/acs.joc.1c00959en_US
dc.identifier.urihttps://doi.org/10.1021/acs.joc.1c00959
dc.identifier.urihttp://hdl.handle.net/1828/14662
dc.language.isoenen_US
dc.publisherThe Journal of Organic Chemistryen_US
dc.subjectAnatomy
dc.subjectFluorescence
dc.subjectKinetic parameters
dc.subjectKinetics
dc.subjectNicotine
dc.subjectCentre for Advanced Materials and Related Technology (CAMTEC)
dc.subject.departmentDepartment of Chemistry
dc.titleMechanism of a disassembly-driven sensing system studied by stopped-flow kineticsen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Bohne_Cornelia_JOrgChem_2021.pdf
Size:
2.56 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Faculty and Staff Publications
 
University of Victoria Libraries

We acknowledge and respect the Lək̓ʷəŋən (Songhees and Esquimalt) Peoples on whose territory the university stands, and the Lək̓ʷəŋən and W̱SÁNEĆ Peoples whose historical relationships with the land continue to this day.