Highly enantiodifferentiating site of human serum albumin for meditating photocyclodimerization of 2-anthracenecarboxylate elucidated by site-specific inhibition/quenching with xenon

Date

2015

Authors

Nishijima, Masaki
Pace, Tamara C. S.
Bohne, Cornelia
Mori, Tadashi
Inoue, Yoshihisa
Wada, Takehiko

Journal Title

Journal ISSN

Volume Title

Publisher

Journal of Photochemistry and Photobiology A: Chemistry

Abstract

Complementary to the previous assignment of the first, second, and fourth binding sites of human serum albumin (HSA) for 2-anthracenecarboxylate (AC) and the subsequent mediation of AC photocyclodimerization, the site-specific inhibition of the enantiodifferentiation by xenon allowed us to assign the remaining third and fifth AC-binding sites to subdomains IB and IIIB, respectively. This study reveals a clearer picture of the binding and photochirogenic behavior of HSA and further expands the scope of bio-supramolecular photochirogenesis.

Description

Keywords

Photochirogenesis, 2-Anthracenecarboxylate, Photocyclodimerization, Human serum albumin, Xenon

Citation

Nishijima, M., Pace, T. C. S., Bohne, C., Mori, T., Inoue, Y., & Wada, T. (2015). Highly enantiodifferentiating site of human serum albumin for meditating photocyclodimerization of 2-anthracenecarboxylate elucidated by site-specific inhibition/quenching with xenon. Journal of Photochemistry and Photobiology A: Chemistry, 331, 89-94. https://doi.org/10.1016/j.jphotochem.2015.12.019.