Marking recovery: Can 3D-MOT training modulate neuroplasticity and inflammatory biomarkers in adults with moderate-severe traumatic brain injury
Date
2026
Authors
Sternig, Katherine
Shill, Isla
Morrison, Jamie
Snowden-Richardson, Taylor
Brand, Justin
Prewett, Pam
Schultz, Sandy
Ehlting, Barbara
Christie, Brian
Journal Title
Journal ISSN
Volume Title
Publisher
University of Victoria
Abstract
My project investigates changes in biomarkers associated with neuroplasticity and inflammation in adults with a history of moderate to severe traumatic brain injury (TBI) following NeuroTracker training, a 3D multiple object tracking (3D-MOT) cognitive training program. Neuroplasticity was assessed through brain-derived neurotrophic factor (BDNF), while inflammatory markers included interleukin-10 (IL-10), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α).
Over 35 participants with moderate to severe TBI were recruited and completed standardized neuropsychological assessments alongside blood and saliva sample collection. Participants were randomly assigned to either an intervention or control group and completed a five-week NeuroTracker training protocol.
My role in the project involved preparing and processing blood samples for biomarker analysis using a Meso Scale Discovery electrochemiluminescence immunoassay. The resulting BDNF concentrations will be analyzed alongside NeuroTracker performance scores to examine potential relationships between cognitive training outcomes and biological markers of neuroplasticity.
Description
Keywords
traumatic brain injury, NeuroTracker, rehabilitation, cognitive training, neuroinflammation, neuroplasticity, Jamie Cassels Undergraduate Research Awards (JCURA)