Marking recovery: Can 3D-MOT training modulate neuroplasticity and inflammatory biomarkers in adults with moderate-severe traumatic brain injury

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dc.contributor.authorSternig, Katherine
dc.contributor.authorShill, Isla
dc.contributor.authorMorrison, Jamie
dc.contributor.authorSnowden-Richardson, Taylor
dc.contributor.authorBrand, Justin
dc.contributor.authorPrewett, Pam
dc.contributor.authorSchultz, Sandy
dc.contributor.authorEhlting, Barbara
dc.contributor.authorChristie, Brian
dc.date.accessioned2026-04-21T21:06:24Z
dc.date.available2026-04-21T21:06:24Z
dc.date.issued2026
dc.description.abstractMy project investigates changes in biomarkers associated with neuroplasticity and inflammation in adults with a history of moderate to severe traumatic brain injury (TBI) following NeuroTracker training, a 3D multiple object tracking (3D-MOT) cognitive training program. Neuroplasticity was assessed through brain-derived neurotrophic factor (BDNF), while inflammatory markers included interleukin-10 (IL-10), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Over 35 participants with moderate to severe TBI were recruited and completed standardized neuropsychological assessments alongside blood and saliva sample collection. Participants were randomly assigned to either an intervention or control group and completed a five-week NeuroTracker training protocol. My role in the project involved preparing and processing blood samples for biomarker analysis using a Meso Scale Discovery electrochemiluminescence immunoassay. The resulting BDNF concentrations will be analyzed alongside NeuroTracker performance scores to examine potential relationships between cognitive training outcomes and biological markers of neuroplasticity.
dc.description.reviewstatusReviewed
dc.description.scholarlevelUndergraduate
dc.description.sponsorshipJamie Cassels Undergraduate Research Awards (JCURA)
dc.identifier.urihttps://hdl.handle.net/1828/23660
dc.language.isoen
dc.publisherUniversity of Victoria
dc.subjecttraumatic brain injury
dc.subjectNeuroTracker
dc.subjectrehabilitation
dc.subjectcognitive training
dc.subjectneuroinflammation
dc.subjectneuroplasticity
dc.subjectJamie Cassels Undergraduate Research Awards (JCURA)
dc.subject.departmentSchool of Medical Sciences
dc.titleMarking recovery: Can 3D-MOT training modulate neuroplasticity and inflammatory biomarkers in adults with moderate-severe traumatic brain injury
dc.typePoster

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