The role of long-lived plasma cells in viral clearance
Date
2024
Authors
Zhang, Mingran
Li, Meili
Ma, Junling
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Biological Dynamics
Abstract
The adaptive immune system has two types of plasma cells (PC), long-lived plasma cells (LLPC) and short-lived plasma cells (SLPC), that differ in their lifespan. In this paper, we propose that LLPC is crucial to the clearance of viral particles in addition to reducing the viral basic reproduction number in secondary infections. We use a sequence of within-host mathematical models to show that, CD8 T cells, SLPC and memory B cells cannot achieve full viral clearance, and the viral load will reach a low positive equilibrium level because of a continuous replenishment of target cells. However, the presence of LLPC is crucial for viral clearance.
Description
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Citation
Zhang, M., Li, M., & Ma, J. (2024). The role of long-lived plasma cells in viral clearance. Journal of Biological Dynamics, 18(1). https://doi.org/10.1080/17513758.2024.2325523