The role of long-lived plasma cells in viral clearance

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dc.contributor.authorZhang, Mingran
dc.contributor.authorLi, Meili
dc.contributor.authorMa, Junling
dc.date.accessioned2024-10-21T19:22:55Z
dc.date.available2024-10-21T19:22:55Z
dc.date.issued2024
dc.description.abstractThe adaptive immune system has two types of plasma cells (PC), long-lived plasma cells (LLPC) and short-lived plasma cells (SLPC), that differ in their lifespan. In this paper, we propose that LLPC is crucial to the clearance of viral particles in addition to reducing the viral basic reproduction number in secondary infections. We use a sequence of within-host mathematical models to show that, CD8 T cells, SLPC and memory B cells cannot achieve full viral clearance, and the viral load will reach a low positive equilibrium level because of a continuous replenishment of target cells. However, the presence of LLPC is crucial for viral clearance.
dc.description.reviewstatusReviewed
dc.description.scholarlevelFaculty
dc.description.sponsorshipWe thank the anonymous reviewers for their constructive comments. This work was supported by the National Natural Science Foundation of China (No. 11771075, 12271088) (ML), Natural Science Foundation of Shanghai (No. 21ZR1401000, No. 23ZR1401700) (ML), and two discovery grants of Natural Sciences and Engineering Research Council Canada (RE, JM), two NSERC EIDM grants (OMNI and MfPH) (JM), and the China Scholarship Council (202106630037) (MZ).
dc.identifier.citationZhang, M., Li, M., & Ma, J. (2024). The role of long-lived plasma cells in viral clearance. Journal of Biological Dynamics, 18(1). https://doi.org/10.1080/17513758.2024.2325523
dc.identifier.urihttps://doi.org/10.1080/17513758.2024.2325523
dc.identifier.urihttps://hdl.handle.net/1828/20611
dc.language.isoen
dc.publisherJournal of Biological Dynamics
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.departmentDepartment of Mathematics and Statistics
dc.titleThe role of long-lived plasma cells in viral clearance
dc.typeArticle

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